Aryl hydrocarbon receptor ( Ahr )‐dependent Il‐22 expression by type 3 innate lymphoid cells control of acute joint inflammation
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چکیده
منابع مشابه
Regulation of Innate Lymphoid Cells by Aryl Hydrocarbon Receptor
With striking similarity to their adaptive T helper cell counterparts, innate lymphoid cells (ILCs) represent an emerging family of cell types that express signature transcription factors, including T-bet+ Eomes+ natural killer cells, T-bet+ Eomes- group 1 ILCs, GATA3+ group 2 ILCs, RORγt+ group 3 ILCs, and newly identified Id3+ regulatory ILC. ILCs are abundantly present in barrier tissues of ...
متن کاملWistar Han Aryl Hydrocarbon Receptor (AhR)
Unknown, but the effects seem limited. Rats homozygous for the mutant allele have a dramatically increased LD50 for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and PCDD (penta-), but not HCDD (hexa-). Overall, the tissue distribution and excretion of TCDD in rats homozygous for the AhR mutation is similar to that of the Long-Evans rat, which was used as a dioxin-sensitive control strain. Reprodu...
متن کاملOver-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study
BACKGROUND Dioxins and related compounds are suspected of causing neurological disruption in human and experimental animal offspring following perinatal exposure during development and growth. The molecular mechanism(s) of the actions in the brain, however, have not been fully investigated. A major participant in the process of the dioxin-toxicity is the dioxin receptor, namely the aryl hydroca...
متن کاملAryl hydrocarbon receptor (AhR)-dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for its toxic responses to man-made pollutants such as dioxin. More recently, the AhR has emerged as a suppressor of inflammation, oxidative stress and apoptosis from cigarette smoke by mechanisms that may involve the regulation of microRNA. However, little is known about the AhR regulation of miRN...
متن کاملInteractions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways.
Most if not all of the toxic responses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through the AhR, which requires ARNT to regulate gene expression. ARNT is also required by HIF-1alpha to enhance the expression of various genes in response to hypoxia. Since both the AhR and hypoxia transcriptional pathways require ARNT, some of the effects of TCDD and similar types of ligands cou...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2021
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.16433